Муцин-16
Муцин-16 (англ. Mucin 16, cell surface associated) – білок, який кодується геном MUC16, розташованим у людини на короткому плечі 19-ї хромосоми.[2] Довжина поліпептидного ланцюга білка становить 14 507 амінокислот, а молекулярна маса — 1 519 175[3].
Послідовність амінокислот
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MLKPSGLPGS | SSPTRSLMTG | SRSTKATPEM | DSGLTGATLS | PKTSTGAIVV | ||||
| TEHTLPFTSP | DKTLASPTSS | VVGRTTQSLG | VMSSALPEST | SRGMTHSEQR | ||||
| TSPSLSPQVN | GTPSRNYPAT | SMVSGLSSPR | TRTSSTEGNF | TKEASTYTLT | ||||
| VETTSGPVTE | KYTVPTETST | TEGDSTETPW | DTRYIPVKIT | SPMKTFADST | ||||
| ASKENAPVSM | TPAETTVTDS | HTPGRTNPSF | GTLYSSFLDL | SPKGTPNSRG | ||||
| ETSLELILST | TGYPFSSPEP | GSAGHSRIST | SAPLSSSASV | LDNKISETSI | ||||
| FSGQSLTSPL | SPGVPEARAS | TMPNSAIPFS | MTLSNAETSA | ERVRSTISSL | ||||
| GTPSISTKQT | AETILTFHAF | AETMDIPSTH | IAKTLASEWL | GSPGTLGGTS | ||||
| TSALTTTSPS | TTLVSEETNT | HHSTSGKETE | GTLNTSMTPL | ETSAPGEESE | ||||
| MTATLVPTLG | FTTLDSKIRS | PSQVSSSHPT | RELRTTGSTS | GRQSSSTAAH | ||||
| GSSDILRATT | SSTSKASSWT | SESTAQQFSE | PQHTQWVETS | PSMKTERPPA | ||||
| STSVAAPITT | SVPSVVSGFT | TLKTSSTKGI | WLEETSADTL | IGESTAGPTT | ||||
| HQFAVPTGIS | MTGGSSTRGS | QGTTHLLTRA | TASSETSADL | TLATNGVPVS | ||||
| VSPAVSKTAA | GSSPPGGTKP | SYTMVSSVIP | ETSSLQSSAF | REGTSLGLTP | ||||
| LNTRHPFSSP | EPDSAGHTKI | STSIPLLSSA | SVLEDKVSAT | STFSHHKATS | ||||
| SITTGTPEIS | TKTKPSSAVL | SSMTLSNAAT | SPERVRNATS | PLTHPSPSGE | ||||
| ETAGSVLTLS | TSAETTDSPN | IHPTGTLTSE | SSESPSTLSL | PSVSGVKTTF | ||||
| SSSTPSTHLF | TSGEETEETS | NPSVSQPETS | VSRVRTTLAS | TSVPTPVFPT | ||||
| MDTWPTRSAQ | FSSSHLVSEL | RATSSTSVTN | STGSALPKIS | HLTGTATMSQ | ||||
| TNRDTFNDSA | APQSTTWPET | SPRFKTGLPS | ATTTVSTSAT | SLSATVMVSK | ||||
| FTSPATSSME | ATSIREPSTT | ILTTETTNGP | GSMAVASTNI | PIGKGYITEG | ||||
| RLDTSHLPIG | TTASSETSMD | FTMAKESVSM | SVSPSQSMDA | AGSSTPGRTS | ||||
| QFVDTFSDDV | YHLTSREITI | PRDGTSSALT | PQMTATHPPS | PDPGSARSTW | ||||
| LGILSSSPSS | PTPKVTMSST | FSTQRVTTSM | IMDTVETSRW | NMPNLPSTTS | ||||
| LTPSNIPTSG | AIGKSTLVPL | DTPSPATSLE | ASEGGLPTLS | TYPESTNTPS | ||||
| IHLGAHASSE | SPSTIKLTMA | SVVKPGSYTP | LTFPSIETHI | HVSTARMAYS | ||||
| SGSSPEMTAP | GETNTGSTWD | PTTYITTTDP | KDTSSAQVST | PHSVRTLRTT | ||||
| ENHPKTESAT | PAAYSGSPKI | SSSPNLTSPA | TKAWTITDTT | EHSTQLHYTK | ||||
| LAEKSSGFET | QSAPGPVSVV | IPTSPTIGSS | TLELTSDVPG | EPLVLAPSEQ | ||||
| TTITLPMATW | LSTSLTEEMA | STDLDISSPS | SPMSTFAIFP | PMSTPSHELS | ||||
| KSEADTSAIR | NTDSTTLDQH | LGIRSLGRTG | DLTTVPITPL | TTTWTSVIEH | ||||
| STQAQDTLSA | TMSPTHVTQS | LKDQTSIPAS | ASPSHLTEVY | PELGTQGRSS | ||||
| SEATTFWKPS | TDTLSREIET | GPTNIQSTPP | MDNTTTGSSS | SGVTLGIAHL | ||||
| PIGTSSPAET | STNMALERRS | STATVSMAGT | MGLLVTSAPG | RSISQSLGRV | ||||
| SSVLSESTTE | GVTDSSKGSS | PRLNTQGNTA | LSSSLEPSYA | EGSQMSTSIP | ||||
| LTSSPTTPDV | EFIGGSTFWT | KEVTTVMTSD | ISKSSARTES | SSATLMSTAL | ||||
| GSTENTGKEK | LRTASMDLPS | PTPSMEVTPW | ISLTLSNAPN | TTDSLDLSHG | ||||
| VHTSSAGTLA | TDRSLNTGVT | RASRLENGSD | TSSKSLSMGN | STHTSMTYTE | ||||
| KSEVSSSIHP | RPETSAPGAE | TTLTSTPGNR | AISLTLPFSS | IPVEEVISTG | ||||
| ITSGPDINSA | PMTHSPITPP | TIVWTSTGTI | EQSTQPLHAV | SSEKVSVQTQ | ||||
| STPYVNSVAV | SASPTHENSV | SSGSSTSSPY | SSASLESLDS | TISRRNAITS | ||||
| WLWDLTTSLP | TTTWPSTSLS | EALSSGHSGV | SNPSSTTTEF | PLFSAASTSA | ||||
| AKQRNPETET | HGPQNTAAST | LNTDASSVTG | LSETPVGASI | SSEVPLPMAI | ||||
| TSRSDVSGLT | SESTANPSLG | TASSAGTKLT | RTISLPTSES | LVSFRMNKDP | ||||
| WTVSIPLGSH | PTTNTETSIP | VNSAGPPGLS | TVASDVIDTP | SDGAESIPTV | ||||
| SFSPSPDTEV | TTISHFPEKT | THSFRTISSL | THELTSRVTP | IPGDWMSSAM | ||||
| STKPTGASPS | ITLGERRTIT | SAAPTTSPIV | LTASFTETST | VSLDNETTVK | ||||
| TSDILDARKT | NELPSDSSSS | SDLINTSIAS | STMDVTKTAS | ISPTSISGMT | ||||
| ASSSPSLFSS | DRPQVPTSTT | ETNTATSPSV | SSNTYSLDGG | SNVGGTPSTL | ||||
| PPFTITHPVE | TSSALLAWSR | PVRTFSTMVS | TDTASGENPT | SSNSVVTSVP | ||||
| APGTWTSVGS | TTDLPAMGFL | KTSPAGEAHS | LLASTIEPAT | AFTPHLSAAV | ||||
| VTGSSATSEA | SLLTTSESKA | IHSSPQTPTT | PTSGANWETS | ATPESLLVVT | ||||
| ETSDTTLTSK | ILVTDTILFS | TVSTPPSKFP | STGTLSGASF | PTLLPDTPAI | ||||
| PLTATEPTSS | LATSFDSTPL | VTIASDSLGT | VPETTLTMSE | TSNGDALVLK | ||||
| TVSNPDRSIP | GITIQGVTES | PLHPSSTSPS | KIVAPRNTTY | EGSITVALST | ||||
| LPAGTTGSLV | FSQSSENSET | TALVDSSAGL | ERASVMPLTT | GSQGMASSGG | ||||
| IRSGSTHSTG | TKTFSSLPLT | MNPGEVTAMS | EITTNRLTAT | QSTAPKGIPV | ||||
| KPTSAESGLL | TPVSASSSPS | KAFASLTTAP | PTWGIPQSTL | TFEFSEVPSL | ||||
| DTKSASLPTP | GQSLNTIPDS | DASTASSSLS | KSPEKNPRAR | MMTSTKAISA | ||||
| SSFQSTGFTE | TPEGSASPSM | AGHEPRVPTS | GTGDPRYASE | SMSYPDPSKA | ||||
| SSAMTSTSLA | SKLTTLFSTG | QAARSGSSSS | PISLSTEKET | SFLSPTASTS | ||||
| RKTSLFLGPS | MARQPNILVH | LQTSALTLSP | TSTLNMSQEE | PPELTSSQTI | ||||
| AEEEGTTAET | QTLTFTPSET | PTSLLPVSSP | TEPTARRKSS | PETWASSISV | ||||
| PAKTSLVETT | DGTLVTTIKM | SSQAAQGNST | WPAPAEETGS | SPAGTSPGSP | ||||
| EMSTTLKIMS | SKEPSISPEI | RSTVRNSPWK | TPETTVPMET | TVEPVTLQST | ||||
| ALGSGSTSIS | HLPTGTTSPT | KSPTENMLAT | ERVSLSPSPP | EAWTNLYSGT | ||||
| PGGTRQSLAT | MSSVSLESPT | ARSITGTGQQ | SSPELVSKTT | GMEFSMWHGS | ||||
| TGGTTGDTHV | SLSTSSNILE | DPVTSPNSVS | SLTDKSKHKT | ETWVSTTAIP | ||||
| STVLNNKIMA | AEQQTSRSVD | EAYSSTSSWS | DQTSGSDITL | GASPDVTNTL | ||||
| YITSTAQTTS | LVSLPSGDQG | ITSLTNPSGG | KTSSASSVTS | PSIGLETLRA | ||||
| NVSAVKSDIA | PTAGHLSQTS | SPAEVSILDV | TTAPTPGIST | TITTMGTNSI | ||||
| STTTPNPEVG | MSTMDSTPAT | ERRTTSTEHP | STWSSTAASD | SWTVTDMTSN | ||||
| LKVARSPGTI | STMHTTSFLA | SSTELDSMST | PHGRITVIGT | SLVTPSSDAS | ||||
| AVKTETSTSE | RTLSPSDTTA | STPISTFSRV | QRMSISVPDI | LSTSWTPSST | ||||
| EAEDVPVSMV | STDHASTKTD | PNTPLSTFLF | DSLSTLDWDT | GRSLSSATAT | ||||
| TSAPQGATTP | QELTLETMIS | PATSQLPFSI | GHITSAVTPA | AMARSSGVTF | ||||
| SRPDPTSKKA | EQTSTQLPTT | TSAHPGQVPR | SAATTLDVIP | HTAKTPDATF | ||||
| QRQGQTALTT | EARATSDSWN | EKEKSTPSAP | WITEMMNSVS | EDTIKEVTSS | ||||
| SSVLRTLNTL | DINLESGTTS | SPSWKSSPYE | RIAPSESTTD | KEAIHPSTNT | ||||
| VETTGWVTSS | EHASHSTIPA | HSASSKLTSP | VVTTSTREQA | IVSMSTTTWP | ||||
| ESTRARTEPN | SFLTIELRDV | SPYMDTSSTT | QTSIISSPGS | TAITKGPRTE | ||||
| ITSSKRISSS | FLAQSMRSSD | SPSEAITRLS | NFPAMTESGG | MILAMQTSPP | ||||
| GATSLSAPTL | DTSATASWTG | TPLATTQRFT | YSEKTTLFSK | GPEDTSQPSP | ||||
| PSVEETSSSS | SLVPIHATTS | PSNILLTSQG | HSPSSTPPVT | SVFLSETSGL | ||||
| GKTTDMSRIS | LEPGTSLPPN | LSSTAGEALS | TYEASRDTKA | IHHSADTAVT | ||||
| NMEATSSEYS | PIPGHTKPSK | ATSPLVTSHI | MGDITSSTSV | FGSSETTEIE | ||||
| TVSSVNQGLQ | ERSTSQVASS | ATETSTVITH | VSSGDATTHV | TKTQATFSSG | ||||
| TSISSPHQFI | TSTNTFTDVS | TNPSTSLIMT | ESSGVTITTQ | TGPTGAATQG | ||||
| PYLLDTSTMP | YLTETPLAVT | PDFMQSEKTT | LISKGPKDVS | WTSPPSVAET | ||||
| SYPSSLTPFL | VTTIPPATST | LQGQHTSSPV | SATSVLTSGL | VKTTDMLNTS | ||||
| MEPVTNSPQN | LNNPSNEILA | TLAATTDIET | IHPSINKAVT | NMGTASSAHV | ||||
| LHSTLPVSSE | PSTATSPMVP | ASSMGDALAS | ISIPGSETTD | IEGEPTSSLT | ||||
| AGRKENSTLQ | EMNSTTESNI | ILSNVSVGAI | TEATKMEVPS | FDATFIPTPA | ||||
| QSTKFPDIFS | VASSRLSNSP | PMTISTHMTT | TQTGSSGATS | KIPLALDTST | ||||
| LETSAGTPSV | VTEGFAHSKI | TTAMNNDVKD | VSQTNPPFQD | EASSPSSQAP | ||||
| VLVTTLPSSV | AFTPQWHSTS | SPVSMSSVLT | SSLVKTAGKV | DTSLETVTSS | ||||
| PQSMSNTLDD | ISVTSAATTD | IETTHPSINT | VVTNVGTTGS | AFESHSTVSA | ||||
| YPEPSKVTSP | NVTTSTMEDT | TISRSIPKSS | KTTRTETETT | SSLTPKLRET | ||||
| SISQEITSST | ETSTVPYKEL | TGATTEVSRT | DVTSSSSTSF | PGPDQSTVSL | ||||
| DISTETNTRL | STSPIMTESA | EITITTQTGP | HGATSQDTFT | MDPSNTTPQA | ||||
| GIHSAMTHGF | SQLDVTTLMS | RIPQDVSWTS | PPSVDKTSSP | SSFLSSPAMT | ||||
| TPSLISSTLP | EDKLSSPMTS | LLTSGLVKIT | DILRTRLEPV | TSSLPNFSST | ||||
| SDKILATSKD | SKDTKEIFPS | INTEETNVKA | NNSGHESHSP | ALADSETPKA | ||||
| TTQMVITTTV | GDPAPSTSMP | VHGSSETTNI | KREPTYFLTP | RLRETSTSQE | ||||
| SSFPTDTSFL | LSKVPTGTIT | EVSSTGVNSS | SKISTPDHDK | STVPPDTFTG | ||||
| EIPRVFTSSI | KTKSAEMTIT | TQASPPESAS | HSTLPLDTST | TLSQGGTHST | ||||
| VTQGFPYSEV | TTLMGMGPGN | VSWMTTPPVE | ETSSVSSLMS | SPAMTSPSPV | ||||
| SSTSPQSIPS | SPLPVTALPT | SVLVTTTDVL | GTTSPESVTS | SPPNLSSITH | ||||
| ERPATYKDTA | HTEAAMHHST | NTAVTNVGTS | GSGHKSQSSV | LADSETSKAT | ||||
| PLMSTTSTLG | DTSVSTSTPN | ISQTNQIQTE | PTASLSPRLR | ESSTSEKTSS | ||||
| TTETNTAFSY | VPTGAITQAS | RTEISSSRTS | ISDLDRPTIA | PDISTGMITR | ||||
| LFTSPIMTKS | AEMTVTTQTT | TPGATSQGIL | PWDTSTTLFQ | GGTHSTVSQG | ||||
| FPHSEITTLR | SRTPGDVSWM | TTPPVEETSS | GFSLMSPSMT | SPSPVSSTSP | ||||
| ESIPSSPLPV | TALLTSVLVT | TTNVLGTTSP | EPVTSSPPNL | SSPTQERLTT | ||||
| YKDTAHTEAM | HASMHTNTAV | ANVGTSISGH | ESQSSVPADS | HTSKATSPMG | ||||
| ITFAMGDTSV | STSTPAFFET | RIQTESTSSL | IPGLRDTRTS | EEINTVTETS | ||||
| TVLSEVPTTT | TTEVSRTEVI | TSSRTTISGP | DHSKMSPYIS | TETITRLSTF | ||||
| PFVTGSTEMA | ITNQTGPIGT | ISQATLTLDT | SSTASWEGTH | SPVTQRFPHS | ||||
| EETTTMSRST | KGVSWQSPPS | VEETSSPSSP | VPLPAITSHS | SLYSAVSGSS | ||||
| PTSALPVTSL | LTSGRRKTID | MLDTHSELVT | SSLPSASSFS | GEILTSEAST | ||||
| NTETIHFSEN | TAETNMGTTN | SMHKLHSSVS | IHSQPSGHTP | PKVTGSMMED | ||||
| AIVSTSTPGS | PETKNVDRDS | TSPLTPELKE | DSTALVMNST | TESNTVFSSV | ||||
| SLDAATEVSR | AEVTYYDPTF | MPASAQSTKS | PDISPEASSS | HSNSPPLTIS | ||||
| THKTIATQTG | PSGVTSLGQL | TLDTSTIATS | AGTPSARTQD | FVDSETTSVM | ||||
| NNDLNDVLKT | SPFSAEEANS | LSSQAPLLVT | TSPSPVTSTL | QEHSTSSLVS | ||||
| VTSVPTPTLA | KITDMDTNLE | PVTRSPQNLR | NTLATSEATT | DTHTMHPSIN | ||||
| TAVANVGTTS | SPNEFYFTVS | PDSDPYKATS | AVVITSTSGD | SIVSTSMPRS | ||||
| SAMKKIESET | TFSLIFRLRE | TSTSQKIGSS | SDTSTVFDKA | FTAATTEVSR | ||||
| TELTSSSRTS | IQGTEKPTMS | PDTSTRSVTM | LSTFAGLTKS | EERTIATQTG | ||||
| PHRATSQGTL | TWDTSITTSQ | AGTHSAMTHG | FSQLDLSTLT | SRVPEYISGT | ||||
| SPPSVEKTSS | SSSLLSLPAI | TSPSPVPTTL | PESRPSSPVH | LTSLPTSGLV | ||||
| KTTDMLASVA | SLPPNLGSTS | HKIPTTSEDI | KDTEKMYPST | NIAVTNVGTT | ||||
| TSEKESYSSV | PAYSEPPKVT | SPMVTSFNIR | DTIVSTSMPG | SSEITRIEME | ||||
| STFSLAHGLK | GTSTSQDPIV | STEKSAVLHK | LTTGATETSR | TEVASSRRTS | ||||
| IPGPDHSTES | PDISTEVIPS | LPISLGITES | SNMTIITRTG | PPLGSTSQGT | ||||
| FTLDTPTTSS | RAGTHSMATQ | EFPHSEMTTV | MNKDPEILSW | TIPPSIEKTS | ||||
| FSSSLMPSPA | MTSPPVSSTL | PKTIHTTPSP | MTSLLTPSLV | MTTDTLGTSP | ||||
| EPTTSSPPNL | SSTSHEILTT | DEDTTAIEAM | HPSTSTAATN | VETTSSGHGS | ||||
| QSSVLADSEK | TKATAPMDTT | STMGHTTVST | SMSVSSETTK | IKRESTYSLT | ||||
| PGLRETSISQ | NASFSTDTSI | VLSEVPTGTT | AEVSRTEVTS | SGRTSIPGPS | ||||
| QSTVLPEIST | RTMTRLFASP | TMTESAEMTI | PTQTGPSGST | SQDTLTLDTS | ||||
| TTKSQAKTHS | TLTQRFPHSE | MTTLMSRGPG | DMSWQSSPSL | ENPSSLPSLL | ||||
| SLPATTSPPP | ISSTLPVTIS | SSPLPVTSLL | TSSPVTTTDM | LHTSPELVTS | ||||
| SPPKLSHTSD | ERLTTGKDTT | NTEAVHPSTN | TAASNVEIPS | SGHESPSSAL | ||||
| ADSETSKATS | PMFITSTQED | TTVAISTPHF | LETSRIQKES | ISSLSPKLRE | ||||
| TGSSVETSSA | IETSAVLSEV | SIGATTEISR | TEVTSSSRTS | ISGSAESTML | ||||
| PEISTTRKII | KFPTSPILAE | SSEMTIKTQT | SPPGSTSEST | FTLDTSTTPS | ||||
| LVITHSTMTQ | RLPHSEITTL | VSRGAGDVPR | PSSLPVEETS | PPSSQLSLSA | ||||
| MISPSPVSST | LPASSHSSSA | SVTSLLTPGQ | VKTTEVLDAS | AEPETSSPPS | ||||
| LSSTSVEILA | TSEVTTDTEK | IHPFSNTAVT | KVGTSSSGHE | SPSSVLPDSE | ||||
| TTKATSAMGT | ISIMGDTSVS | TLTPALSNTR | KIQSEPASSL | TTRLRETSTS | ||||
| EETSLATEAN | TVLSKVSTGA | TTEVSRTEAI | SFSRTSMSGP | EQSTMSQDIS | ||||
| IGTIPRISAS | SVLTESAKMT | ITTQTGPSES | TLESTLNLNT | ATTPSWVETH | ||||
| SIVIQGFPHP | EMTTSMGRGP | GGVSWPSPPF | VKETSPPSSP | LSLPAVTSPH | ||||
| PVSTTFLAHI | PPSPLPVTSL | LTSGPATTTD | ILGTSTEPGT | SSSSSLSTTS | ||||
| HERLTTYKDT | AHTEAVHPST | NTGGTNVATT | SSGYKSQSSV | LADSSPMCTT | ||||
| STMGDTSVLT | STPAFLETRR | IQTELASSLT | PGLRESSGSE | GTSSGTKMST | ||||
| VLSKVPTGAT | TEISKEDVTS | IPGPAQSTIS | PDISTRTVSW | FSTSPVMTES | ||||
| AEITMNTHTS | PLGATTQGTS | TLDTSSTTSL | TMTHSTISQG | FSHSQMSTLM | ||||
| RRGPEDVSWM | SPPLLEKTRP | SFSLMSSPAT | TSPSPVSSTL | PESISSSPLP | ||||
| VTSLLTSGLA | KTTDMLHKSS | EPVTNSPANL | SSTSVEILAT | SEVTTDTEKT | ||||
| HPSSNRTVTD | VGTSSSGHES | TSFVLADSQT | SKVTSPMVIT | STMEDTSVST | ||||
| STPGFFETSR | IQTEPTSSLT | LGLRKTSSSE | GTSLATEMST | VLSGVPTGAT | ||||
| AEVSRTEVTS | SSRTSISGFA | QLTVSPETST | ETITRLPTSS | IMTESAEMMI | ||||
| KTQTDPPGST | PESTHTVDIS | TTPNWVETHS | TVTQRFSHSE | MTTLVSRSPG | ||||
| DMLWPSQSSV | EETSSASSLL | SLPATTSPSP | VSSTLVEDFP | SASLPVTSLL | ||||
| NPGLVITTDR | MGISREPGTS | STSNLSSTSH | ERLTTLEDTV | DTEDMQPSTH | ||||
| TAVTNVRTSI | SGHESQSSVL | SDSETPKATS | PMGTTYTMGE | TSVSISTSDF | ||||
| FETSRIQIEP | TSSLTSGLRE | TSSSERISSA | TEGSTVLSEV | PSGATTEVSR | ||||
| TEVISSRGTS | MSGPDQFTIS | PDISTEAITR | LSTSPIMTES | AESAITIETG | ||||
| SPGATSEGTL | TLDTSTTTFW | SGTHSTASPG | FSHSEMTTLM | SRTPGDVPWP | ||||
| SLPSVEEASS | VSSSLSSPAM | TSTSFFSTLP | ESISSSPHPV | TALLTLGPVK | ||||
| TTDMLRTSSE | PETSSPPNLS | STSAEILATS | EVTKDREKIH | PSSNTPVVNV | ||||
| GTVIYKHLSP | SSVLADLVTT | KPTSPMATTS | TLGNTSVSTS | TPAFPETMMT | ||||
| QPTSSLTSGL | REISTSQETS | SATERSASLS | GMPTGATTKV | SRTEALSLGR | ||||
| TSTPGPAQST | ISPEISTETI | TRISTPLTTT | GSAEMTITPK | TGHSGASSQG | ||||
| TFTLDTSSRA | SWPGTHSAAT | HRSPHSGMTT | PMSRGPEDVS | WPSRPSVEKT | ||||
| SPPSSLVSLS | AVTSPSPLYS | TPSESSHSSP | LRVTSLFTPV | MMKTTDMLDT | ||||
| SLEPVTTSPP | SMNITSDESL | ATSKATMETE | AIQLSENTAV | TQMGTISARQ | ||||
| EFYSSYPGLP | EPSKVTSPVV | TSSTIKDIVS | TTIPASSEIT | RIEMESTSTL | ||||
| TPTPRETSTS | QEIHSATKPS | TVPYKALTSA | TIEDSMTQVM | SSSRGPSPDQ | ||||
| STMSQDISTE | VITRLSTSPI | KTESTEMTIT | TQTGSPGATS | RGTLTLDTST | ||||
| TFMSGTHSTA | SQGFSHSQMT | ALMSRTPGDV | PWLSHPSVEE | ASSASFSLSS | ||||
| PVMTSSSPVS | STLPDSIHSS | SLPVTSLLTS | GLVKTTELLG | TSSEPETSSP | ||||
| PNLSSTSAEI | LAITEVTTDT | EKLEMTNVVT | SGYTHESPSS | VLADSVTTKA | ||||
| TSSMGITYPT | GDTNVLTSTP | AFSDTSRIQT | KSKLSLTPGL | METSISEETS | ||||
| SATEKSTVLS | SVPTGATTEV | SRTEAISSSR | TSIPGPAQST | MSSDTSMETI | ||||
| TRISTPLTRK | ESTDMAITPK | TGPSGATSQG | TFTLDSSSTA | SWPGTHSATT | ||||
| QRFPQSVVTT | PMSRGPEDVS | WPSPLSVEKN | SPPSSLVSSS | SVTSPSPLYS | ||||
| TPSGSSHSSP | VPVTSLFTSI | MMKATDMLDA | SLEPETTSAP | NMNITSDESL | ||||
| AASKATTETE | AIHVFENTAA | SHVETTSATE | ELYSSSPGFS | EPTKVISPVV | ||||
| TSSSIRDNMV | STTMPGSSGI | TRIEIESMSS | LTPGLRETRT | SQDITSSTET | ||||
| STVLYKMPSG | ATPEVSRTEV | MPSSRTSIPG | PAQSTMSLDI | SDEVVTRLST | ||||
| SPIMTESAEI | TITTQTGYSL | ATSQVTLPLG | TSMTFLSGTH | STMSQGLSHS | ||||
| EMTNLMSRGP | ESLSWTSPRF | VETTRSSSSL | TSLPLTTSLS | PVSSTLLDSS | ||||
| PSSPLPVTSL | ILPGLVKTTE | VLDTSSEPKT | SSSPNLSSTS | VEIPATSEIM | ||||
| TDTEKIHPSS | NTAVAKVRTS | SSVHESHSSV | LADSETTITI | PSMGITSAVD | ||||
| DTTVFTSNPA | FSETRRIPTE | PTFSLTPGFR | ETSTSEETTS | ITETSAVLYG | ||||
| VPTSATTEVS | MTEIMSSNRI | HIPDSDQSTM | SPDIITEVIT | RLSSSSMMSE | ||||
| STQMTITTQK | SSPGATAQST | LTLATTTAPL | ARTHSTVPPR | FLHSEMTTLM | ||||
| SRSPENPSWK | SSLFVEKTSS | SSSLLSLPVT | TSPSVSSTLP | QSIPSSSFSV | ||||
| TSLLTPGMVK | TTDTSTEPGT | SLSPNLSGTS | VEILAASEVT | TDTEKIHPSS | ||||
| SMAVTNVGTT | SSGHELYSSV | SIHSEPSKAT | YPVGTPSSMA | ETSISTSMPA | ||||
| NFETTGFEAE | PFSHLTSGFR | KTNMSLDTSS | VTPTNTPSSP | GSTHLLQSSK | ||||
| TDFTSSAKTS | SPDWPPASQY | TEIPVDIITP | FNASPSITES | TGITSFPESR | ||||
| FTMSVTESTH | HLSTDLLPSA | ETISTGTVMP | SLSEAMTSFA | TTGVPRAISG | ||||
| SGSPFSRTES | GPGDATLSTI | AESLPSSTPV | PFSSSTFTTT | DSSTIPALHE | ||||
| ITSSSATPYR | VDTSLGTESS | TTEGRLVMVS | TLDTSSQPGR | TSSSPILDTR | ||||
| MTESVELGTV | TSAYQVPSLS | TRLTRTDGIM | EHITKIPNEA | AHRGTIRPVK | ||||
| GPQTSTSPAS | PKGLHTGGTK | RMETTTTALK | TTTTALKTTS | RATLTTSVYT | ||||
| PTLGTLTPLN | ASMQMASTIP | TEMMITTPYV | FPDVPETTSS | LATSLGAETS | ||||
| TALPRTTPSV | FNRESETTAS | LVSRSGAERS | PVIQTLDVSS | SEPDTTASWV | ||||
| IHPAETIPTV | SKTTPNFFHS | ELDTVSSTAT | SHGADVSSAI | PTNISPSELD | ||||
| ALTPLVTISG | TDTSTTFPTL | TKSPHETETR | TTWLTHPAET | SSTIPRTIPN | ||||
| FSHHESDATP | SIATSPGAET | SSAIPIMTVS | PGAEDLVTSQ | VTSSGTDRNM | ||||
| TIPTLTLSPG | EPKTIASLVT | HPEAQTSSAI | PTSTISPAVS | RLVTSMVTSL | ||||
| AAKTSTTNRA | LTNSPGEPAT | TVSLVTHPAQ | TSPTVPWTTS | IFFHSKSDTT | ||||
| PSMTTSHGAE | SSSAVPTPTV | STEVPGVVTP | LVTSSRAVIS | TTIPILTLSP | ||||
| GEPETTPSMA | TSHGEEASSA | IPTPTVSPGV | PGVVTSLVTS | SRAVTSTTIP | ||||
| ILTFSLGEPE | TTPSMATSHG | TEAGSAVPTV | LPEVPGMVTS | LVASSRAVTS | ||||
| TTLPTLTLSP | GEPETTPSMA | TSHGAEASST | VPTVSPEVPG | VVTSLVTSSS | ||||
| GVNSTSIPTL | ILSPGELETT | PSMATSHGAE | ASSAVPTPTV | SPGVSGVVTP | ||||
| LVTSSRAVTS | TTIPILTLSS | SEPETTPSMA | TSHGVEASSA | VLTVSPEVPG | ||||
| MVTSLVTSSR | AVTSTTIPTL | TISSDEPETT | TSLVTHSEAK | MISAIPTLAV | ||||
| SPTVQGLVTS | LVTSSGSETS | AFSNLTVASS | QPETIDSWVA | HPGTEASSVV | ||||
| PTLTVSTGEP | FTNISLVTHP | AESSSTLPRT | TSRFSHSELD | TMPSTVTSPE | ||||
| AESSSAISTT | ISPGIPGVLT | SLVTSSGRDI | SATFPTVPES | PHESEATASW | ||||
| VTHPAVTSTT | VPRTTPNYSH | SEPDTTPSIA | TSPGAEATSD | FPTITVSPDV | ||||
| PDMVTSQVTS | SGTDTSITIP | TLTLSSGEPE | TTTSFITYSE | THTSSAIPTL | ||||
| PVSPGASKML | TSLVISSGTD | STTTFPTLTE | TPYEPETTAI | QLIHPAETNT | ||||
| MVPRTTPKFS | HSKSDTTLPV | AITSPGPEAS | SAVSTTTISP | DMSDLVTSLV | ||||
| PSSGTDTSTT | FPTLSETPYE | PETTATWLTH | PAETSTTVSG | TIPNFSHRGS | ||||
| DTAPSMVTSP | GVDTRSGVPT | TTIPPSIPGV | VTSQVTSSAT | DTSTAIPTLT | ||||
| PSPGEPETTA | SSATHPGTQT | GFTVPIRTVP | SSEPDTMASW | VTHPPQTSTP | ||||
| VSRTTSSFSH | SSPDATPVMA | TSPRTEASSA | VLTTISPGAP | EMVTSQITSS | ||||
| GAATSTTVPT | LTHSPGMPET | TALLSTHPRT | ETSKTFPAST | VFPQVSETTA | ||||
| SLTIRPGAET | STALPTQTTS | SLFTLLVTGT | SRVDLSPTAS | PGVSAKTAPL | ||||
| STHPGTETST | MIPTSTLSLG | LLETTGLLAT | SSSAETSTST | LTLTVSPAVS | ||||
| GLSSASITTD | KPQTVTSWNT | ETSPSVTSVG | PPEFSRTVTG | TTMTLIPSEM | ||||
| PTPPKTSHGE | GVSPTTILRT | TMVEATNLAT | TGSSPTVAKT | TTTFNTLAGS | ||||
| LFTPLTTPGM | STLASESVTS | RTSYNHRSWI | STTSSYNRRY | WTPATSTPVT | ||||
| STFSPGISTS | SIPSSTAATV | PFMVPFTLNF | TITNLQYEED | MRHPGSRKFN | ||||
| ATERELQGLL | KPLFRNSSLE | YLYSGCRLAS | LRPEKDSSAT | AVDAICTHRP | ||||
| DPEDLGLDRE | RLYWELSNLT | NGIQELGPYT | LDRNSLYVNG | FTHRSSMPTT | ||||
| STPGTSTVDV | GTSGTPSSSP | SPTTAGPLLM | PFTLNFTITN | LQYEEDMRRT | ||||
| GSRKFNTMES | VLQGLLKPLF | KNTSVGPLYS | GCRLTLLRPE | KDGAATGVDA | ||||
| ICTHRLDPKS | PGLNREQLYW | ELSKLTNDIE | ELGPYTLDRN | SLYVNGFTHQ | ||||
| SSVSTTSTPG | TSTVDLRTSG | TPSSLSSPTI | MAAGPLLVPF | TLNFTITNLQ | ||||
| YGEDMGHPGS | RKFNTTERVL | QGLLGPIFKN | TSVGPLYSGC | RLTSLRSEKD | ||||
| GAATGVDAIC | IHHLDPKSPG | LNRERLYWEL | SQLTNGIKEL | GPYTLDRNSL | ||||
| YVNGFTHRTS | VPTSSTPGTS | TVDLGTSGTP | FSLPSPATAG | PLLVLFTLNF | ||||
| TITNLKYEED | MHRPGSRKFN | TTERVLQTLL | GPMFKNTSVG | LLYSGCRLTL | ||||
| LRSEKDGAAT | GVDAICTHRL | DPKSPGVDRE | QLYWELSQLT | NGIKELGPYT | ||||
| LDRNSLYVNG | FTHWIPVPTS | STPGTSTVDL | GSGTPSSLPS | PTTAGPLLVP | ||||
| FTLNFTITNL | KYEEDMHCPG | SRKFNTTERV | LQSLLGPMFK | NTSVGPLYSG | ||||
| CRLTLLRSEK | DGAATGVDAI | CTHRLDPKSP | GVDREQLYWE | LSQLTNGIKE | ||||
| LGPYTLDRNS | LYVNGFTHQT | SAPNTSTPGT | STVDLGTSGT | PSSLPSPTSA | ||||
| GPLLVPFTLN | FTITNLQYEE | DMHHPGSRKF | NTTERVLQGL | LGPMFKNTSV | ||||
| GLLYSGCRLT | LLRPEKNGAA | TGMDAICSHR | LDPKSPGLNR | EQLYWELSQL | ||||
| THGIKELGPY | TLDRNSLYVN | GFTHRSSVAP | TSTPGTSTVD | LGTSGTPSSL | ||||
| PSPTTAVPLL | VPFTLNFTIT | NLQYGEDMRH | PGSRKFNTTE | RVLQGLLGPL | ||||
| FKNSSVGPLY | SGCRLISLRS | EKDGAATGVD | AICTHHLNPQ | SPGLDREQLY | ||||
| WQLSQMTNGI | KELGPYTLDR | NSLYVNGFTH | RSSGLTTSTP | WTSTVDLGTS | ||||
| GTPSPVPSPT | TTGPLLVPFT | LNFTITNLQY | EENMGHPGSR | KFNITESVLQ | ||||
| GLLKPLFKST | SVGPLYSGCR | LTLLRPEKDG | VATRVDAICT | HRPDPKIPGL | ||||
| DRQQLYWELS | QLTHSITELG | PYTLDRDSLY | VNGFTQRSSV | PTTSTPGTFT | ||||
| VQPETSETPS | SLPGPTATGP | VLLPFTLNFT | ITNLQYEEDM | RRPGSRKFNT | ||||
| TERVLQGLLM | PLFKNTSVSS | LYSGCRLTLL | RPEKDGAATR | VDAVCTHRPD | ||||
| PKSPGLDRER | LYWKLSQLTH | GITELGPYTL | DRHSLYVNGF | THQSSMTTTR | ||||
| TPDTSTMHLA | TSRTPASLSG | PMTASPLLVL | FTINFTITNL | RYEENMHHPG | ||||
| SRKFNTTERV | LQGLLRPVFK | NTSVGPLYSG | CRLTLLRPKK | DGAATKVDAI | ||||
| CTYRPDPKSP | GLDREQLYWE | LSQLTHSITE | LGPYTLDRDS | LYVNGFTQRS | ||||
| SVPTTSIPGT | PTVDLGTSGT | PVSKPGPSAA | SPLLVLFTLN | FTITNLRYEE | ||||
| NMQHPGSRKF | NTTERVLQGL | LRSLFKSTSV | GPLYSGCRLT | LLRPEKDGTA | ||||
| TGVDAICTHH | PDPKSPRLDR | EQLYWELSQL | THNITELGPY | ALDNDSLFVN | ||||
| GFTHRSSVST | TSTPGTPTVY | LGASKTPASI | FGPSAASHLL | ILFTLNFTIT | ||||
| NLRYEENMWP | GSRKFNTTER | VLQGLLRPLF | KNTSVGPLYS | GCRLTLLRPE | ||||
| KDGEATGVDA | ICTHRPDPTG | PGLDREQLYL | ELSQLTHSIT | ELGPYTLDRD | ||||
| SLYVNGFTHR | SSVPTTSTGV | VSEEPFTLNF | TINNLRYMAD | MGQPGSLKFN | ||||
| ITDNVMQHLL | SPLFQRSSLG | ARYTGCRVIA | LRSVKNGAET | RVDLLCTYLQ | ||||
| PLSGPGLPIK | QVFHELSQQT | HGITRLGPYS | LDKDSLYLNG | YNEPGPDEPP | ||||
| TTPKPATTFL | PPLSEATTAM | GYHLKTLTLN | FTISNLQYSP | DMGKGSATFN | ||||
| STEGVLQHLL | RPLFQKSSMG | PFYLGCQLIS | LRPEKDGAAT | GVDTTCTYHP | ||||
| DPVGPGLDIQ | QLYWELSQLT | HGVTQLGFYV | LDRDSLFING | YAPQNLSIRG | ||||
| EYQINFHIVN | WNLSNPDPTS | SEYITLLRDI | QDKVTTLYKG | SQLHDTFRFC | ||||
| LVTNLTMDSV | LVTVKALFSS | NLDPSLVEQV | FLDKTLNASF | HWLGSTYQLV | ||||
| DIHVTEMESS | VYQPTSSSST | QHFYLNFTIT | NLPYSQDKAQ | PGTTNYQRNK | ||||
| RNIEDALNQL | FRNSSIKSYF | SDCQVSTFRS | VPNRHHTGVD | SLCNFSPLAR | ||||
| RVDRVAIYEE | FLRMTRNGTQ | LQNFTLDRSS | VLVDGYSPNR | NEPLTGNSDL | ||||
| PFWAVILIGL | AGLLGVITCL | ICGVLVTTRR | RKKEGEYNVQ | QQCPGYYQSH | ||||
| LDLEDLQ |
| MUC16 | |||||||||||||||||
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| Ідентифікатори | |||||||||||||||||
| Символи | MUC16, CA125, mucin 16, cell surface associated | ||||||||||||||||
| Зовнішні ІД | OMIM: 606154 HomoloGene: 133291 GeneCards: MUC16 | ||||||||||||||||
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| Види | Людина | Миша | |||||||||||||||
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| RefSeq (білок) |
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| Локус (UCSC) | Хр. 19: 8.85 – 8.98 Mb | н/д | |||||||||||||||
| PubMed search | [1] | н/д | |||||||||||||||
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Кодований геном білок за функцією належить до фосфопротеїнів. Локалізований у клітинній мембрані, а його фрагмент також секретований назовні.
Фізіологічна роль
Муцин-16 синтезується в клітинах епітелію бронхів, ендометрію, яєчників, рогівки. Низка протеаз, зокрема еластаза нейтрофілів, MMP7, MMP9, бактеріальна металопротеаза ZmpC тощо, здатні відщеплювати позаклітинну частину білка від трансмембранного якоря. Функція білка в здорових клітинах маловивчена, хоча встановлено, що в епітелії ока муцин-16 взаємодіє з галектином-3 та цей комплекс захищає око від вірусних та бактеріальних інфекцій.[4]
Медичне значення
1981 року група американських онкологів під керівництвом Роберта Баста (англ. Robert C. Bast) розробила моноклональне антитіло OC125, яке позитивно реагувало з тканиною злоякісної пухлини яєчника, але не взаємодіяло з іншими типами пухлин цього органу. Невідомий на той час білок, який розпізнавало це антитіло, був названий CA125 (від англ. Cancer Antigen). Попри те, що антитіло було створено задля лікування цього виду раку, надалі його почали використовувати для діагностики, зокрема щодо рецидивів раку яєчників. 2001 року було клоновано ген, який кодує цей білок, який виявився приналежним до родини муцинів. [5]
Висока експресія білка на поверхні ракових клітин захищає їх від моноцитів та природних кілерів[4].
Див. також
Література
- O'Brien T.J., Beard J.B., Underwood L.J., Shigemasa K. (2002). The CA 125 gene: a newly discovered extension of the glycosylated N-terminal domain doubles the size of this extracellular superstructure.. Tumor Biol. 23: 154 — 169. PubMed DOI:10.1159/000064032
- Yin B.W.T., Lloyd K.O. (2001). Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16.. J. Biol. Chem. 276: 27371 — 27375. PubMed DOI:10.1074/jbc.M103554200
- McLemore M.R., Aouizerat B. (2005). Introducing the MUC16 gene: implications for prevention and early detection in epithelial ovarian cancer.. Biol. Res. Nurs. 6: 262 — 267. PubMed DOI:10.1177/1099800404274445
- Argueso P., Tisdale A., Spurr-Michaud S., Sumiyoshi M., Gipson I.K. (2006). Mucin characteristics of human corneal-limbal epithelial cells that exclude the rose bengal anionic dye.. Invest. Ophthalmol. Vis. Sci. 47: 113 — 119. PubMed DOI:10.1167/iovs.05-0735
Примітки
- Human PubMed Reference:.
- HUGO Gene Nomenclature Commitee, HGNC:15582 (англ.). Процитовано 12 вересня 2017.
- UniProt, Q8WXI7 (англ.). Процитовано 12 вересня 2017.
- Felder, Mildred; Kapur, Arvinder; Gonzalez-Bosquet, Jesus; Horibata, Sachi; Heintz, Joseph; Albrecht, Ralph; Fass, Lucas; Kaur, Justanjyot; Hu, Kevin; Shojaei, Hadi; Whelan, Rebecca J; Patankar, Manish S (2014). MUC16 (CA125): tumor biomarker to cancer therapy, a work in progress. Molecular Cancer 13 (1): 129. ISSN 1476-4598. doi:10.1186/1476-4598-13-129.(англ.)
- Das, S.; Batra, S. K. (2015). Understanding the Unique Attributes of MUC16 (CA125): Potential Implications in Targeted Therapy. Cancer Research 75 (22): 4669–4674. ISSN 0008-5472. doi:10.1158/0008-5472.CAN-15-1050.(англ.)
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